Journal Issue: Br J Clin Pharmacol Volume 86(12);  2020 Dec

Logo of brjclinpharmLink to Publisher's site
Journal List

Volume 86(12);  2020 Dec

Issue Highlights

Issue highlights
Br J Clin Pharmacol. 2020 Dec; 86(12): 2331–2332. Published online 2020 Nov 25. doi: 10.1111/bcp.14640
PMCID:
PMC7688548
Article PDF–235K

Editorial

Regulatory science: Regulation is too important to leave it to the regulators
Hubert G. Leufkens
Br J Clin Pharmacol. 2020 Dec; 86(12): 2333–2334. Published online 2019 Apr 10. doi: 10.1111/bcp.13917
PMCID:
PMC7688532
Article PDF–147K

Spotlight Commentary

Effect of pharmaceutical regulatory policy on health impact
Jennifer H. Martin
Br J Clin Pharmacol. 2020 Dec; 86(12): 2335–2337. Published online 2020 Jun 14. doi: 10.1111/bcp.14390
PMCID:
PMC7688524
Article PDF–348K

Original Articles

Risk assessment of using off‐label morphine sulfate in a population‐based retrospective cohort of opioid‐dependent patients
Célian Bertin, Jessica Delorme, Marie Riquelme, Hélène Peyrière, Georges Brousse, Alain Eschalier, Denis Ardid, Chouki Chenaf, Nicolas Authier
Br J Clin Pharmacol. 2020 Dec; 86(12): 2338–2348. Published online 2019 Aug 24. doi: 10.1111/bcp.14082
PMCID:
PMC7688539
Abstract Article PDF–794K
Real‐world evaluation of the impact of statin intensity on adherence and persistence to therapy: A Scottish population‐based study
Renata Cristina Rezende Macedo do Nascimento, Tanja Mueller, Brian Godman, Sean MacBride Stewart, Simon Hurding, Francisco de Assis Acurcio, Augusto Afonso Guerra Junior, Juliana Alvares Teodoro, Alec Morton, Marion Bennie, Amanj Kurdi
Br J Clin Pharmacol. 2020 Dec; 86(12): 2349–2361. Published online 2020 May 30. doi: 10.1111/bcp.14333
PMCID:
PMC7688536
Abstract Article PDF–1.1M
Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake
Anne Keunecke, Sven Hoefman, Henk‐Jan Drenth, Jochen Zisowsky, Adriaan Cleton, Bart A. Ploeger
Br J Clin Pharmacol. 2020 Dec; 86(12): 2362–2376. Published online 2020 Jun 10. doi: 10.1111/bcp.14334
PMCID:
PMC7688542
Abstract Article PDF–1.6M
Dutch trends in the use of potentially harmful medication during pregnancy
Eline Houben, Bernke te Winkel, Eric A. P. Steegers, Ron M. C. Herings
Br J Clin Pharmacol. 2020 Dec; 86(12): 2377–2392. Published online 2020 May 26. doi: 10.1111/bcp.14341
PMCID:
PMC7688525
Abstract Article PDF–1.3M
Reporting rates of adverse reactions to specialty care medicines exhibit a direct positive correlation with patient exposure: A lack of evidence for the Weber effect
Vikas Modgill, Léa Dormegny, David J. Lewis
Br J Clin Pharmacol. 2020 Dec; 86(12): 2393–2403. Published online 2020 May 28. doi: 10.1111/bcp.14342
PMCID:
PMC7688531
Abstract Article PDF–2.4M
Usefulness of therapeutic drug monitoring of rilpivirine and its relationship with virologic response and resistance in a cohort of naive and pretreated HIV‐infected patients
Nadège Néant, Minh Patrick Lê, Naïm Bouazza, Florence Gattacceca, Yazdan Yazdanpanah, Catherine Dhiver, Sylvie Bregigeon, Saadia Mokhtari, Gilles Peytavin, Catherine Tamalet, Diane Descamps, Bruno Lacarelle, Caroline Solas
Br J Clin Pharmacol. 2020 Dec; 86(12): 2404–2413. Published online 2020 Jun 1. doi: 10.1111/bcp.14344
PMCID:
PMC7688528
Abstract Article PDF–1.7M
Potentially inappropriate medication use and related hospital admissions in aged care residents: The impact of dementia
Tesfahun C. Eshetie, Greg Roberts, Tuan A. Nguyen, Marianne H. Gillam, Dorsa Maher, Lisa M. Kalisch Ellett
Br J Clin Pharmacol. 2020 Dec; 86(12): 2414–2423. Published online 2020 Jun 1. doi: 10.1111/bcp.14345
PMCID:
PMC7688547
Abstract Article PDF–790K
Bioequivalence of macitentan and tadalafil given as fixed‐dose combination or single‐component tablets in healthy subjects
Simon Grill, Shirin Bruderer, Patricia N. Sidharta, Mariya Antonova, Susanne Globig, James Carlson, Armin Schultz, Dénes Csonka
Br J Clin Pharmacol. 2020 Dec; 86(12): 2424–2434. Published online 2020 May 29. doi: 10.1111/bcp.14347
PMCID:
PMC7688529
Abstract Article PDF–1.0M
Pregabalin poisoning and rising recreational use: a retrospective observational series
Katherine Z. Isoardi, Gregory Polkinghorne, Keith Harris, Geoffrey K. Isbister
Br J Clin Pharmacol. 2020 Dec; 86(12): 2435–2440. Published online 2020 Jun 5. doi: 10.1111/bcp.14348
PMCID:
PMC7688538
Abstract Article PDF–709K
Effectiveness of a multicomponent pharmacist intervention at hospital discharge for drug‐related problems: A cluster randomised cross‐over trial
Xavier Pourrat, Clémence Leyrat, Benoît Allenet, Brigitte Bouzige, Armelle Develay, Martial Fraysse, Valérie Garnier, Jean‐Michel Halimi, Clarisse Roux‐Marson, Bruno Giraudeau
Br J Clin Pharmacol. 2020 Dec; 86(12): 2441–2454. Published online 2020 Jun 7. doi: 10.1111/bcp.14349
PMCID:
PMC7688527
Abstract Article PDF–8.7M
Association of different oral anticoagulants use with renal function worsening in patients with atrial fibrillation: A multicentre cohort study
Daniele Pastori, Evaristo Ettorre, Gregory Y.H. Lip, Angela Sciacqua, Francesco Perticone, Francesco Melillo, Cosmo Godino, Rossella Marcucci, Martina Berteotti, Francesco Violi, Pasquale Pignatelli, Mirella Saliola, Danilo Menichelli, Marco Antonio Casciaro, Vito Menafra
Br J Clin Pharmacol. 2020 Dec; 86(12): 2455–2463. Published online 2020 Jun 7. doi: 10.1111/bcp.14350
PMCID:
PMC7688543
Abstract Article PDF–1.4M
Drug monitoring for mycophenolic acid in graft‐vs‐host disease prophylaxis in cord blood transplantation
Hiroyuki Muranushi, Junya Kanda, Yasuyuki Arai, Takero Shindo, Masakatsu Hishizawa, Takashi Yamamoto, Tadakazu Kondo, Kohei Yamashita, Kazuo Matsubara, Akifumi Takaori‐Kondo
Br J Clin Pharmacol. 2020 Dec; 86(12): 2464–2472. Published online 2020 May 30. doi: 10.1111/bcp.14354
PMCID:
PMC7688537
Abstract Article PDF–1.5M
Impact of granulocyte colony‐stimulating factor on FOLFIRINOX‐induced neutropenia prevention: A population pharmacokinetic/pharmacodynamic approach
Pauline Macaire, Justine Paris, Julie Vincent, François Ghiringhelli, Leïla Bengrine‐Lefevre, Antonin Schmitt
Br J Clin Pharmacol. 2020 Dec; 86(12): 2473–2485. Published online 2020 Jun 5. doi: 10.1111/bcp.14356
PMCID:
PMC7688541
Abstract Article PDF–4.5M
A pharmacokinetic‐pharmacodynamic study of a single dose of febuxostat in healthy subjects
Bishoy Kamel, Garry G. Graham, Sophie L. Stocker, Zhixin Liu, Kenneth M. Williams, Jane E. Carland, Kevin D. Pile, Richard O. Day
Br J Clin Pharmacol. 2020 Dec; 86(12): 2486–2496. Published online 2020 Jun 18. doi: 10.1111/bcp.14357
PMCID:
PMC7688545
Abstract Article PDF–2.2M
Prospective validation of a model‐informed precision dosing tool for vancomycin in intensive care patients
Rob ter Heine, Ron J. Keizer, Krista van Steeg, Elise J. Smolders, Matthijs van Luin, Hieronymus J. Derijks, Cornelis P.C. de Jager, Tim Frenzel, Roger Brüggemann
Br J Clin Pharmacol. 2020 Dec; 86(12): 2497–2506. Published online 2020 Jun 5. doi: 10.1111/bcp.14360
PMCID:
PMC7688533
Abstract Article PDF–1.0M
The first‐in‐human study of CNTO 7160, an anti‐interleukin‐33 receptor monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis
Ivo Nnane, Bart Frederick, Zhenling Yao, Donald Raible, Cathye Shu, Philipp Badorrek, Maarten van den Boer, Patrick Branigan, Karen Duffy, Frédéric Baribaud, Damien Fink, Tong‐Yuan Yang, Zhenhua Xu
Br J Clin Pharmacol. 2020 Dec; 86(12): 2507–2518. Published online 2020 Jun 14. doi: 10.1111/bcp.14361
PMCID:
PMC7688540
Abstract Article PDF–2.2M
Major bleeding risk associated with oral anticoagulant in real clinical practice. A multicentre 3‐year period population‐based prospective cohort study
Jacques Bouget, Frédéric Balusson, Maxime Maignan, Laure Pavageau, Pierre‐Marie Roy, Karine Lacut, Lucie‐Marie Scailteux, Emmanuel Nowak, Emmanuel Oger
Br J Clin Pharmacol. 2020 Dec; 86(12): 2519–2529. Published online 2020 Jun 1. doi: 10.1111/bcp.14362
PMCID:
PMC7688535
Abstract Article PDF–3.7M

Short Report

Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model
Philip A. Hines, Richard H. Guy, Angela Brand, Anthony J. Humphreys, Marisa Papaluca‐Amati
Br J Clin Pharmacol. 2020 Dec; 86(12): 2530–2534. Published online 2019 Oct 17. doi: 10.1111/bcp.14099
PMCID:
PMC7688530
Abstract Article PDF–773K

Letters to the Editor

Why dose adjust systemic exposure when looking for associations with adverse events in tacrolimus‐treated transplant recipients?
Ida Robertsen, Jean‐Baptiste Woillard, Anders Åsberg
Br J Clin Pharmacol. 2020 Dec; 86(12): 2535. Published online 2019 May 29. doi: 10.1111/bcp.13984
PMCID:
PMC7688523
Article PDF–189K
Problems with paper entitled The impact of tacrolimus exposure on extrarenal adverse effects in adult transplant recipients
Terry E. Jones
Br J Clin Pharmacol. 2020 Dec; 86(12): 2536–2537. Published online 2019 Dec 17. doi: 10.1111/bcp.14106
PMCID:
PMC7688521
Article PDF–244K
Statins and glycaemic control in type 2 diabetes: Are bile acids relevant?
Daniel J. Sansome, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Tongzhi Wu
Br J Clin Pharmacol. 2020 Dec; 86(12): 2538–2539. Published online 2020 Mar 30. doi: 10.1111/bcp.14274
PMCID:
PMC7688544
Article PDF–227K
Response to ‘comment on “associations of statin use with glycemic traits and incident type 2 diabetes”’
Fariba Ahmadizar, Bruno H. Stricker
Br J Clin Pharmacol. 2020 Dec; 86(12): 2540–2541. Published online 2020 May 22. doi: 10.1111/bcp.14323
PMCID:
PMC7688546
Article PDF–220K
Identifying lithium‐poisoned patients who may benefit from haemodialysis remains highly challenging
Dominique Vodovar, Minh P. Lê, Laurence Labat, Bruno Mégarbane
Br J Clin Pharmacol. 2020 Dec; 86(12): 2542–2543. Published online 2020 Jun 2. doi: 10.1111/bcp.14366
PMCID:
PMC7688526
Article PDF–231K
Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society