Journal Issue: Antimicrob Agents Chemother Volume 68(8);  2024 Aug

Logo of aacLink to Publisher's site
Journal List

Volume 68(8);  2024 Aug

Minireview

Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps
Valeria Gigante, Richard A. Alm, Daniela Melchiorri, Tamarie Rocke, Cesar A. Arias, Lloyd Czaplewski, Prabhavathi Fernandes, François Franceschi, Stephan Harbarth, Roman Kozlov, Christian Lienhardt, Norio Ohmagari, Lesley A. Ogilvie, Mical Paul, John H. Rex, Lynn L. Silver, Melvin Spigelman, Hatim Sati, Alexandra M. Cameron
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00535-24. Published online 2024 Jul 15. doi: 10.1128/aac.00535-24
PMCID:
PMC11304740
Abstract Article PDF–608K

Mechanisms of Resistance

EfpA is required for regrowth of Mycobacterium tuberculosis following isoniazid exposure
Adam H. Roberts, Christopher W. Moon, Valwynne Faulkner, Sharon L. Kendall, Simon J. Waddell, Joanna Bacon
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00261-24. Published online 2024 Jul 22. doi: 10.1128/aac.00261-24
PMCID:
PMC11304720
Abstract Article PDF–2.0M
The intrinsic macrolide resistome of Escherichia coli
Yibing Ma, Mattia Pirolo, Bimal Jana, Viktor Hundtofte Mebus, Luca Guardabassi
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00452-24. Published online 2024 Jun 28. doi: 10.1128/aac.00452-24
PMCID:
PMC11304742
Abstract Article PDF–1.2M

Antiviral Agents

Pharmacokinetics and safety of GST-HG171, a novel 3CL protease inhibitor, in Chinese subjects with impaired and normal liver function
Jing Zhou, Hong Zhang, Hong Chen, George Zhang, John Mao, Tianxiang Zhang, Yanan Tang, Wenhao Yan, Chuanjing Li, Yanhua Ding, Qinglong Jin
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00539-24. Published online 2024 Jul 11. doi: 10.1128/aac.00539-24
PMCID:
PMC11304707
Abstract Article PDF–662K
H2 inhalation therapy in patients with moderate COVID-19 (H2COVID): a prospective ascending-dose phase I clinical trial
C. Salomez-Ihl, J. Giai, M. Barbado, A. Paris, S. Touati, J. P. Alcaraz, S. Tanguy, C. Leroy, A. Lehmann, B. Degano, M. Gavard, P. Bedouch, P. Pavese, A. Moreau-Gaudry, M. Roustit, F. Boucher, P. Cinquin, J. P. Brion
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00573-24. Published online 2024 Jul 17. doi: 10.1128/aac.00573-24
PMCID:
PMC11304737
Abstract Article PDF–772K

Experimental Therapeutics

Zafirlukast induces DNA condensation and has bactericidal effect on replicating Mycobacterium abscessus
Sanne van der Niet, Keith D. Green, Irene M. Schimmel, Jordy de Bakker, Bastiaan Lodder, Eric A. Reits, Sylvie Garneau-Tsodikova, Nicole N. van der Wel
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00029-24. Published online 2024 Jul 11. doi: 10.1128/aac.00029-24
PMCID:
PMC11304721
Abstract Article PDF–3.4M
Identification of novel bromodomain inhibitors of Trypanosoma cruzi bromodomain factor 2 (TcBDF2) using a fluorescence polarization-based high-throughput assay
Luis E. Tavernelli, Victoria L. Alonso, Imanol Peña, Elvio Rodríguez Araya, Romina Manarin, Juan Cantizani, Julio Martin, Juan Salamanca, Paul Bamborough, Felix Calderón, Raquel Gabarro, Esteban Serra
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00243-24. Published online 2024 Jul 19. doi: 10.1128/aac.00243-24
PMCID:
PMC11304739
Abstract Article PDF–634K
A phase 1 open label study to assess the human mass balance and metabolite profile of 14C-fosmanogepix, a novel Gwt-1 inhibitor in healthy male participants
Michael R. Hodges, Eric Ople, Philip Evans, A. J. (Andre) Pantophlet, Jessica Richardson, Dylan Williams, Sakambari Tripathy, Margaret Tawadrous, Abhijeet Jakate
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00273-24. Published online 2024 Jul 16. doi: 10.1128/aac.00273-24
PMCID:
PMC11304685
Abstract Article PDF–1.8M

Clinical Therapeutics

Thorough QT/QTc study to evaluate the effect of a single supratherapeutic dose of islatravir on QTc interval prolongation in healthy adults
Randolph P. Matthews, Yang Liu, Catherine Matthews, Kristin L. Butterfield, Terry O'Reilly, S. Aubrey Stoch, Marian Iwamoto
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00464-24. Published online 2024 Jul 2. doi: 10.1128/aac.00464-24
PMCID:
PMC11304681
Abstract Article PDF–1.1M
Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip
Janet Conway, Ronald E. Delanois, Michael A. Mont, Alexandra Stavrakis, Edward McPherson, Edward Stolarski, Stephen Incavo, Daniel Oakes, Ralph Salvagno, John S. Adams, Adriane Kisch-Hancock, Edgar Tenorio, Anton Leighton, Stefan Ryser, Lawrence M. Kauvar, Nicholas M. Bernthal
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00655-24. Published online 2024 Jul 16. doi: 10.1128/aac.00655-24
PMCID:
PMC11304715
Abstract Article PDF–460K

Pharmacology

Population pharmacokinetics of rifabutin among HIV/TB co-infected children on lopinavir/ritonavir-based antiretroviral therapy
Manna Semere Gebreyesus, Roeland E. Wasmann, Helen McIlleron, Regina Oladokun, Prosper Okonkwo, Lubbe Wiesner, Paolo Denti, Holly E. Rawizza
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00354-24. Published online 2024 Jul 22. doi: 10.1128/aac.00354-24
PMCID:
PMC11304744
Abstract Article PDF–3.9M
Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis
Sean Wasserman, Rosleine Antilus-Sainte, Noha Abdelgawad, Narineh M. Odjourian, Melissa Cristaldo, Maureen Dougher, Firat Kaya, Matthew Zimmerman, Paolo Denti, Martin Gengenbacher
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00783-24. Published online 2024 Jul 19. doi: 10.1128/aac.00783-24
PMCID:
PMC11304741
Abstract Article PDF–633K

Letters to the Editor

Concerns about the interpretation of treatment effects
Shougen Sumiyoshi
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00695-24. Published online 2024 Jul 16. doi: 10.1128/aac.00695-24
PMCID:
PMC11304734
Article PDF–107K
Reply to Sumiyoshi, “Concerns about the interpretation of treatment effects”
Xin Gu, Pingyu Zhou
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00723-24. Published online 2024 Jul 16. doi: 10.1128/aac.00723-24
PMCID:
PMC11304676
Article PDF–143K

Author Corrections

Correction for Huang et al., “In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori”
Yanqiang Huang, Xudong Hang, Xueqing Jiang, Liping Zeng, Jia Jia, Yong Xie, Fei Li, Hongkai Bi
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00672-24. Published online 2024 Jun 28. doi: 10.1128/aac.00672-24
Corrects:
Antimicrob Agents Chemother. 2019 Jun; 63(6): e00004-19.
PMCID:
PMC11304738
Correction PDF–304K
Correction for Van Gulck et al., “A truncated HIV Tat demonstrates potent and specific latency reversal activity”
Ellen Van Gulck, Marion Pardons, Erik Nijs, Nick Verheyen, Koen Dockx, Christel Van Den Eynde, Emilie Battivelli, Jerel Vega, Eric Florence, Brigitte Autran, Nancie M. Archin, David M. Margolis, Christine Katlama, Chiraz Hamimi, Ilse Van Den Wyngaert, Filmon Eyassu, Linos Vandekerckhove, Daniel Boden
Antimicrob Agents Chemother. 2024 Aug; 68(8): e00819-24. Published online 2024 Jul 2. doi: 10.1128/aac.00819-24
Corrects:
Antimicrob Agents Chemother. 2023 Nov; 67(11): e00417-23.
PMCID:
PMC11304713
Correction PDF–224K
Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)