Journal Issue: Br J Pharmacol Volume 177(24);  2020 Dec

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Journal List

Volume 177(24);  2020 Dec

TARGETING THE NITRIC OXIDE (NO)‐cGMP PATHWAY: THERAPEUTIC OPPORTUNITIES IN THE 21ST CENTURY

Nitric oxide signalling in the brain and its control of bodily functions
Konstantina Chachlaki, Vincent Prevot
Br J Pharmacol. 2020 Dec; 177(24): 5437–5458. Published online 2019 Sep 8. doi: 10.1111/bph.14800
PMCID:
PMC7707094
Abstract Article PDF–2.4M
NO and hepatocellular cancer
Ronghua Wang, David A. Geller, David A. Wink, Bin Cheng, Timothy R. Billiar
Br J Pharmacol. 2020 Dec; 177(24): 5459–5466. Published online 2019 Dec 11. doi: 10.1111/bph.14838
PMCID:
PMC7707086
Abstract Article PDF–1.8M
Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease
Nikolaos Tzoumas, Tariq E. Farrah, Neeraj Dhaun, David J. Webb
Br J Pharmacol. 2020 Dec; 177(24): 5467–5488. Published online 2020 Feb 4. doi: 10.1111/bph.14920
PMCID:
PMC7707100
Abstract Article PDF–5.6M

Review Articles

Function and therapeutic potential of G protein‐coupled receptors in epididymis
Daolai Zhang, Yanfei Wang, Hui Lin, Yujing Sun, Mingwei Wang, Yingli Jia, Xiao Yu, Hui Jiang, Wenming Xu, Jin‐Peng Sun, Zhigang Xu
Br J Pharmacol. 2020 Dec; 177(24): 5489–5508. Published online 2020 Oct 29. doi: 10.1111/bph.15252
PMCID:
PMC7707088
Abstract Article PDF–4.8M
Development of cannabidiol as a treatment for severe childhood epilepsies
Claire M. Williams, Gary J. Stephens
Br J Pharmacol. 2020 Dec; 177(24): 5509–5517. Published online 2020 Oct 27. doi: 10.1111/bph.15274
PMCID:
PMC7707087
Abstract Article PDF–1.6M

Research Papers

Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans
Rob C. van Wijk, Wanbin Hu, Sharka M. Dijkema, Dirk‐Jan van den Berg, Jeremy Liu, Rida Bahi, Fons J. Verbeek, Ulrika S.H. Simonsson, Herman P. Spaink, Piet H. van der Graaf, Elke H.J. Krekels
Br J Pharmacol. 2020 Dec; 177(24): 5518–5533. Published online 2020 Nov 3. doi: 10.1111/bph.15247
PMCID:
PMC7707096
Abstract Article PDF–11M
Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity
Leena Otsomaa, Jouko Levijoki, Gerd Wohlfahrt, Hugh Chapman, Ari‐Pekka Koivisto, Kaisa Syrjänen, Tuula Koskelainen, Saara‐Elisa Peltokorpi, Piet Finckenberg, Aira Heikkilä, Najah Abi‐Gerges, Andre Ghetti, Paul E. Miller, Guy Page, Eero Mervaala, Norbert Nagy, Zsófia Kohajda, Norbert Jost, László Virág, András Varró, Julius Gy. Papp
Br J Pharmacol. 2020 Dec; 177(24): 5534–5554. Published online 2020 Nov 10. doi: 10.1111/bph.15257
PMCID:
PMC7707092
Abstract Article PDF–14M
Preclinical studies investigating the neural mechanisms involved in the co‐morbidity of migraine and temporomandibular disorders: the role of CGRP
Simon Akerman, Marcela Romero‐Reyes
Br J Pharmacol. 2020 Dec; 177(24): 5555–5568. Published online 2020 Oct 21. doi: 10.1111/bph.15263
PMCID:
PMC7707098
Abstract Article PDF–17M
Methnaridine is an orally bioavailable, fast‐killing and long‐acting antimalarial agent that cures Plasmodium infections in mice
Weisi Wang, Junmin Yao, Zhuo Chen, Yiming Sun, Yuqing Shi, Yufen Wei, Hejun Zhou, Yingfang Yu, Shizhu Li, Liping Duan
Br J Pharmacol. 2020 Dec; 177(24): 5569–5579. Published online 2020 Oct 30. doi: 10.1111/bph.15268
PMCID:
PMC7707099
Abstract Article PDF–3.6M
Metabolic effects of carvedilol through β‐arrestin proteins: investigations in a streptozotocin‐induced diabetes rat model and in C2C12 myoblasts
Berna Güven, Zümra Kara, Arzu Onay‐Beşikci
Br J Pharmacol. 2020 Dec; 177(24): 5580–5594. Published online 2020 Nov 15. doi: 10.1111/bph.15269
Correction in:
Br J Pharmacol, volume 178 on page 2370
PMCID:
PMC7707093
Abstract Article PDF–6.4M
Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors
Praveen Kumar, Petra Scholze, Martin Fronius, Gabriela Krasteva‐Christ, Monika I. Hollenhorst
Br J Pharmacol. 2020 Dec; 177(24): 5595–5608. Published online 2020 Nov 9. doi: 10.1111/bph.15270
PMCID:
PMC7707097
Abstract Article PDF–5.0M
Effects of mavacamten on Ca2+ sensitivity of contraction as sarcomere length varied in human myocardium
Peter O. Awinda, Yemeserach Bishaw, Marissa Watanabe, Maya A. Guglin, Kenneth S. Campbell, Bertrand C. W. Tanner
Br J Pharmacol. 2020 Dec; 177(24): 5609–5621. Published online 2020 Oct 21. doi: 10.1111/bph.15271
PMCID:
PMC7707091
Abstract Article PDF–2.9M
Rho kinase inhibitor fasudil reduces l‐DOPA‐induced dyskinesia in a rat model of Parkinson's disease
Andrea Lopez‐Lopez, Carmen M. Labandeira, Jose L. Labandeira‐Garcia, Ana Muñoz
Br J Pharmacol. 2020 Dec; 177(24): 5622–5641. Published online 2020 Nov 3. doi: 10.1111/bph.15275
PMCID:
PMC7707090
Abstract Article PDF–26M
Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel
Ya‐Kun Huang, Yu‐Gang Lu, Xin Zhao, Jing‐Bing Zhang, Feng‐Ming Zhang, Yong Chen, Ling‐Bo Bi, Jia‐Hui Gu, Zuo‐Jie Jiang, Xiao‐Man Wu, Qing‐Yi Li, Yanli Liu, Jian‐Xin Shen, Xing‐Jun Liu
Br J Pharmacol. 2020 Dec; 177(24): 5642–5657. Published online 2020 Nov 16. doi: 10.1111/bph.15284
PMCID:
PMC7707095
Abstract Article PDF–35M
Glycogen synthase kinase‐3 inhibition rescues sex‐dependent contextual fear memory deficit in human immunodeficiency virus‐1 transgenic mice
Shamsudheen Moidunny, Michael A. Benneyworth, David J. Titus, Eleonore Beurel, Udhghatri Kolli, Joyce Meints, Richa Jalodia, Sundaram Ramakrishnan, Coleen M. Atkins, Sabita Roy
Br J Pharmacol. 2020 Dec; 177(24): 5658–5676. Published online 2020 Nov 23. doi: 10.1111/bph.15288
PMCID:
PMC7707089
Abstract Article PDF–19M

Letters to the Editor

Is the C3a receptor antagonist SB290157 a useful pharmacological tool?
John D. Lee, Stephen M. Taylor, Trent M. Woodruff
Br J Pharmacol. 2020 Dec; 177(24): 5677–5678. Published online 2020 Oct 18. doi: 10.1111/bph.15264
PMCID:
PMC7707084
Article PDF–465K
Update on animal models for COVID‐19 research
Simon J. Cleary, Mélia Magnen, Mark R. Looney, Clive P. Page
Br J Pharmacol. 2020 Dec; 177(24): 5679–5681. Published online 2020 Nov 2. doi: 10.1111/bph.15266
PMCID:
PMC7707085
Article PDF–579K
Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society