Journal Issue: AAPS PharmSciTech Volume 17(2);  2016 Apr

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Journal List

Volume 17(2);  2016 Apr

Research Articles

Quality-by-Design II: Application of Quantitative Risk Analysis to the Formulation of Ciprofloxacin Tablets
H. Gregg Claycamp, Ravikanth Kona, Raafat Fahmy, Stephen W. Hoag
AAPS PharmSciTech. 2016 Apr; 17(2): 233–244. Published online 2015 Jul 23. doi: 10.1208/s12249-015-0349-2
PMCID:
PMC4984889
Abstract Article PDF–1012K
Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration
Karl J. Box, John Comer, Robert Taylor, Shyam Karki, Rebeca Ruiz, Robert Price, Nikoletta Fotaki
AAPS PharmSciTech. 2016 Apr; 17(2): 245–251. Published online 2015 Jul 25. doi: 10.1208/s12249-015-0362-5
PMCID:
PMC4984899
Abstract Article PDF–361K
Microparticles Containing Curcumin Solid Dispersion: Stability, Bioavailability and Anti-Inflammatory Activity
C. C. C. Teixeira, L. M. Mendonça, M. M. Bergamaschi, R. H. C. Queiroz, G. E. P. Souza, L. M. G. Antunes, L. A. P. Freitas
AAPS PharmSciTech. 2016 Apr; 17(2): 252–261. Published online 2015 Jun 4. doi: 10.1208/s12249-015-0337-6
PMCID:
PMC4984877
Abstract Article PDF–541K
Design and Evaluation of a Novel Felbinac Transdermal Patch: Combining Ion-Pair and Chemical Enhancer Strategy
Nannan Liu, Wenting Song, Tian Song, Liang Fang
AAPS PharmSciTech. 2016 Apr; 17(2): 262–271. Published online 2015 Jun 13. doi: 10.1208/s12249-015-0342-9
PMCID:
PMC4984900
Abstract Article PDF–457K
Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances
Kale Mohana Raghava Srivalli, Brahmeshwar Mishra
AAPS PharmSciTech. 2016 Apr; 17(2): 272–283. Published online 2015 Jun 16. doi: 10.1208/s12249-015-0344-7
PMCID:
PMC4984878
Abstract Article PDF–743K
Drop-on-Demand System for Manufacturing of Melt-based Solid Oral Dosage: Effect of Critical Process Parameters on Product Quality
Elçin Içten, Arun Giridhar, Zoltan K. Nagy, Gintaras V. Reklaitis
AAPS PharmSciTech. 2016 Apr; 17(2): 284–293. Published online 2015 Jun 17. doi: 10.1208/s12249-015-0348-3
PMCID:
PMC4984897
Abstract Article PDF–730K
Nanoparticle-Based Topical Ophthalmic Gel Formulation for Sustained Release of Hydrocortisone Butyrate
Xiaoyan Yang, Hoang M. Trinh, Vibhuti Agrahari, Ye Sheng, Dhananjay Pal, Ashim K. Mitra
AAPS PharmSciTech. 2016 Apr; 17(2): 294–306. Published online 2015 Jun 18. doi: 10.1208/s12249-015-0354-5
PMCID:
PMC4984892
Abstract Article PDF–672K
Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies
Soma Sengupta, Sarita Banerjee, Biswadip Sinha, Biswajit Mukherjee
AAPS PharmSciTech. 2016 Apr; 17(2): 307–317. Published online 2015 Jun 19. doi: 10.1208/s12249-015-0347-4
PMCID:
PMC4984882
Abstract Article PDF–512K
Construction and Validation of Binary Phase Diagram for Amorphous Solid Dispersion Using Flory–Huggins Theory
Krishna Bansal, Uttam Singh Baghel, Seema Thakral
AAPS PharmSciTech. 2016 Apr; 17(2): 318–327. Published online 2015 Jun 20. doi: 10.1208/s12249-015-0343-8
PMCID:
PMC4984891
Abstract Article PDF–410K
Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits
Rehab Mohammad Yusif, Irhan Ibrahim Abu Hashim, Elham Abdelmonem Mohamed, Farid Abd-Elreheim Badria
AAPS PharmSciTech. 2016 Apr; 17(2): 328–338. Published online 2015 Jun 20. doi: 10.1208/s12249-015-0351-8
PMCID:
PMC4984873
Abstract Article PDF–460K
Preparation and In Vitro–In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability
Ya Zhang, Zhimin Huang, E. Omari-Siaw, Shuang Lu, Yuan Zhu, Dongmei Jiang, Miaomiao Wang, Jiangnan Yu, Ximing Xu, Weiming Zhang
AAPS PharmSciTech. 2016 Apr; 17(2): 339–349. Published online 2015 Jul 1. doi: 10.1208/s12249-015-0352-7
PMCID:
PMC4984881
Abstract Article PDF–374K
Development and Optimization of a Novel Prolonged Release Formulation to Resist Alcohol-Induced Dose Dumping
Chaitanya Yogananda Gujjar, Balaramesha Chary Rallabandi, Ramesh Gannu, Vallabh Subashrao Deulkar
AAPS PharmSciTech. 2016 Apr; 17(2): 350–357. Published online 2015 Jul 11. doi: 10.1208/s12249-015-0358-1
PMCID:
PMC4984876
Abstract Article PDF–623K
Ilex paraguariensis Pellets from a Spray-Dried Extract: Development, Characterization, and Stability
Francini K. J. Yatsu, Greice S. Borghetti, Fagner Magalhães, Humberto G. Ferraz, Eloir Paulo Schenkel, Valquiria L. Bassani
AAPS PharmSciTech. 2016 Apr; 17(2): 358–367. Published online 2015 Jul 11. doi: 10.1208/s12249-015-0361-6
PMCID:
PMC4984883
Abstract Article PDF–588K
A Quality by Experimental Design Approach to Assess the Effect of Formulation and Process Variables on the Extrusion and Spheronization of Drug-Loaded Pellets Containing Polyplasdone® XL-10
Kalyan K. Saripella, Nikhil C. Loka, Rama Mallipeddi, Anuja M. Rane, Steven H. Neau
AAPS PharmSciTech. 2016 Apr; 17(2): 368–379. Published online 2015 Jul 14. doi: 10.1208/s12249-015-0345-6
PMCID:
PMC4984875
Abstract Article PDF–6.2M
Effects of Temperature and Humidity on Laser Diffraction Measurements to Jet Nebulizer and Comparison with NGI
Xinghan Song, Junhua Hu, Shuyao Zhan, Rui Zhang, Wen Tan
AAPS PharmSciTech. 2016 Apr; 17(2): 380–388. Published online 2015 Jul 14. doi: 10.1208/s12249-015-0346-5
PMCID:
PMC4984894
Abstract Article PDF–588K
An Intensified Vibratory Milling Process for Enhancing the Breakage Kinetics during the Preparation of Drug Nanosuspensions
Meng Li, Lu Zhang, Rajesh N. Davé, Ecevit Bilgili
AAPS PharmSciTech. 2016 Apr; 17(2): 389–399. Published online 2015 Jul 17. doi: 10.1208/s12249-015-0364-3
PMCID:
PMC4984880
Abstract Article PDF–617K
Nanosuspensions Containing Oridonin/HP-β-Cyclodextrin Inclusion Complexes for Oral Bioavailability Enhancement via Improved Dissolution and Permeability
Xingwang Zhang, Tianpeng Zhang, Yali Lan, Baojian Wu, Zhihai Shi
AAPS PharmSciTech. 2016 Apr; 17(2): 400–408. Published online 2015 Jul 18. doi: 10.1208/s12249-015-0363-4
PMCID:
PMC4984896
Abstract Article PDF–489K
Development, Optimization, and Characterization of PEGylated Nanoemulsion of Prostaglandin E1 for Long Circulation
Ying Cheng, Miao Liu, Huijing Hu, Daozhou Liu, Siyuan Zhou
AAPS PharmSciTech. 2016 Apr; 17(2): 409–417. Published online 2015 Jul 21. doi: 10.1208/s12249-015-0366-1
PMCID:
PMC4984874
Abstract Article PDF–345K
pH-Dependent Solubility and Dissolution Behavior of Carvedilol—Case Example of a Weakly Basic BCS Class II Drug
Rania Hamed, Areeg Awadallah, Suhair Sunoqrot, Ola Tarawneh, Sami Nazzal, Tamadur AlBaraghthi, Jihan Al Sayyad, Aiman Abbas
AAPS PharmSciTech. 2016 Apr; 17(2): 418–426. Published online 2015 Jul 23. doi: 10.1208/s12249-015-0365-2
PMCID:
PMC4984888
Abstract Article PDF–337K
Solid-State Characterization and Interconversion of Recrystallized Amodiaquine Dihydrochloride in Aliphatic Monohydric Alcohols
Wiriyaporn Sirikun, Jittima Chatchawalsaisin, Narueporn Sutanthavibul
AAPS PharmSciTech. 2016 Apr; 17(2): 427–435. Published online 2015 Jul 24. doi: 10.1208/s12249-015-0355-4
PMCID:
PMC4984895
Abstract Article PDF–477K
Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel
Nilesh R. Rarokar, Suprit D. Saoji, Nishikant A. Raut, Jayashree B. Taksande, Pramod B. Khedekar, Vivek S. Dave
AAPS PharmSciTech. 2016 Apr; 17(2): 436–445. Published online 2015 Jul 25. doi: 10.1208/s12249-015-0369-y
PMCID:
PMC4984890
Abstract Article PDF–668K
Glutamine-Loaded Liposomes: Preliminary Investigation, Characterization, and Evaluation of Neutrophil Viability
Larissa Chaves Costa, Bárbara Nayane Rosário Fernandes Souza, Fábio Fidélis Almeida, Cláudia Jacques Lagranha, Pabyton Gonçalves Cadena, Nereide Stela Santos-Magalhães, Mariane Cajubá de Britto Lira-Nogueira
AAPS PharmSciTech. 2016 Apr; 17(2): 446–453. Published online 2015 Jul 31. doi: 10.1208/s12249-015-0375-0
PMCID:
PMC4984898
Abstract Article PDF–367K
QbD-Enabled Development of Novel Stimuli-Responsive Gastroretentive Systems of Acyclovir for Improved Patient Compliance and Biopharmaceutical Performance
Bhupinder Singh, Anterpreet Kaur, Shashi Dhiman, Babita Garg, Rajneet Kaur Khurana, Sarwar Beg
AAPS PharmSciTech. 2016 Apr; 17(2): 454–465. Published online 2015 Aug 4. doi: 10.1208/s12249-015-0367-0
PMCID:
PMC4984879
Abstract Article PDF–834K
Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib
Duy Hieu Truong, Tuan Hiep Tran, Thiruganesh Ramasamy, Ju Yeon Choi, Hee Hyun Lee, Cheol Moon, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
AAPS PharmSciTech. 2016 Apr; 17(2): 466–473. Published online 2015 Aug 4. doi: 10.1208/s12249-015-0370-5
PMCID:
PMC4984901
Abstract Article PDF–641K
Assessment of the Dissociation Energetics of Some Selected Ligand Drugs Bound on Human Serum Albumin by Differential Scanning Calorimetry
Damrongsak Faroongsarng
AAPS PharmSciTech. 2016 Apr; 17(2): 474–481. Published online 2015 Aug 6. doi: 10.1208/s12249-015-0372-3
PMCID:
PMC6548420
Abstract Article PDF–431K
Encapsulation of Mentha Oil in Chitosan Polymer Matrix Alleviates Skin Irritation
Nidhi Mishra, Vineet Kumar Rai, Kuldeep Singh Yadav, Priyam Sinha, Archana Kanaujia, Debabrata Chanda, Apurva Jakhmola, Dharmendra Saikia, Narayan Prasad Yadav
AAPS PharmSciTech. 2016 Apr; 17(2): 482–492. Published online 2015 Aug 8. doi: 10.1208/s12249-015-0378-x
PMCID:
PMC4984886
Abstract Article PDF–763K
Coatings of Eudragit® RL and L-55 Blends: Investigations on the Drug Release Mechanism
Robert Wulff, Claudia S. Leopold
AAPS PharmSciTech. 2016 Apr; 17(2): 493–503. Published online 2015 Aug 12. doi: 10.1208/s12249-015-0377-y
PMCID:
PMC4984893
Abstract Article PDF–573K
Compression-Coated Tablet for Colon Targeting: Impact of Coating and Core Materials on Drug Release
Siddhartha Maity, Biswanath Sa
AAPS PharmSciTech. 2016 Apr; 17(2): 504–515. Published online 2015 Aug 14. doi: 10.1208/s12249-015-0359-0
PMCID:
PMC4984885
Abstract Article PDF–572K

Brief/Technical Note

Acceptance Probability (Pa) Analysis for Process Validation Lifecycle Stages
Daniel Alsmeyer, Ajay Pazhayattil, Shu Chen, Francesco Munaretto, Maksuda Hye, Pradeep Sanghvi
AAPS PharmSciTech. 2016 Apr; 17(2): 516–522. Published online 2015 May 30. doi: 10.1208/s12249-015-0338-5
PMCID:
PMC4984884
Abstract Article PDF–405K
Process and Method Variability Modeling to Achieve QbD Targets
Mark Alasandro, Thomas A. Little
AAPS PharmSciTech. 2016 Apr; 17(2): 523–527. Published online 2015 Aug 12. doi: 10.1208/s12249-015-0380-3
PMCID:
PMC4984887
Abstract Article PDF–703K
Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists